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NSAID Exposure Not Linked to Risk of Spontaneous Abortion
No risk for specific drugs, with the exception of significantly increased risk for indomethacin

WEDNESDAY, Feb. 5, 2014 (HealthDay News) -- Fetal nonsteroidal anti-inflammatory drug (NSAID) exposure is not an independent risk factor for spontaneous abortion, according to a study published online Feb. 3 in CMAJ, the journal of the Canadian Medical Association.

Sharon Daniel, M.D., M.P.H., from Ben Gurion University of the Negev in Beer-Sheva, Israel, and colleagues performed a historical cohort study involving 65,457 women who conceived between January 2003 and December 2009. The authors sought to assess the correlation between fetal NSAID exposure and the risk of spontaneous abortion.

The researchers found that 90.1 percent of the women who conceived during the study period were admitted for a birth and 9.9 percent were admitted for a spontaneous abortion. During the study period, 6.9 percent of women were exposed to NSAIDs. There was no independent association between exposure to NSAIDs and spontaneous abortion (nonselective cyclooxygenase [COX] inhibitors: adjusted hazard ratio [HR], 1.10 [95 percent confidence interval (CI), 0.90 to 1.22]; selective COX-2 inhibitors: adjusted HR, 1.43 [95 percent CI, 0.79 to 2.59]). No increased risk was seen for specific NSAID drugs, with the exception of indomethacin (adjusted HR, 2.8; 95 percent CI, 1.70 to 4.69). No dose-response effect was observed.

"We found no increased risk of spontaneous abortion following exposure to NSAIDs," the authors write. "Further research is needed to assess the risk following exposure to selective COX-2 inhibitors."

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