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Children of Obese Mothers at Higher Risk of Early Death
Maternal obesity during pregnancy ups risk of premature death in adult offspring

WEDNESDAY, Aug. 14 (HealthDay News) -- Adult offspring of mothers who were obese during the pregnancy are at greater risk for early death and hospital admissions for cardiovascular events, according to research published online Aug. 13 in BMJ.

Rebecca M. Reynolds, M.D., Ph.D., of the University of Edinburgh in the United Kingdom, and colleagues conducted a record linkage cohort analysis of 37,709 individuals with birth records from 1950 to the present to assess the association between maternal obesity during pregnancy and mortality from cardiovascular events in adult offspring.

The researchers found that after multivariable adjustment, offspring of obese mothers (body mass index greater than 30 kg/m²) had increased all-cause mortality (hazard ratio, 1.35) and increased risk of hospital admission for a cardiovascular event (hazard ratio, 1.29). Adult children of overweight mothers also had a higher risk of adverse outcomes.

"Our data build on the literature showing associations between excess maternal weight and adverse health in the offspring," the authors write. "Our findings highlight the urgent need for strategies to prevent obesity in women of childbearing age and the need to assess the offspring of obese mothers for their cardiovascular risk."

Two authors disclosed financial ties to pharmaceutical companies.

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